Animal liver microsomes are isolated from liver tissue of preclinical species such as rat, mouse, dog, and monkey, providing a high-quality in vitro system for evaluating Phase I metabolic activity. Rich in cytochrome P450 enzymes and optimized for consistent performance, these microsomes are ideal for studies in drug metabolism, enzyme kinetics, inhibition, and IVIVE studies.
Each batch undergoes rigorous quality control to ensure high protein concentration, preserved enzymatic activity, and reproducibility across experiments. Animal liver microsomes offer a dependable platform for screening metabolic stability, identifying major metabolites, and supporting regulatory toxicology and pharmacokinetics studies
Animal Liver Microsomes
Species: Rat, Mouse, Dog, Monkey (others available upon request)
10 mg of protein/vial, 0,5 mL
Total CYP ≥ 0.2 nmol/mg protein (species-dependent)
Measured CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2E1, CYP3A4/5Metabolic stability (Phase I)
Metabolite Identification
CYP Inhibition