Our human intestinal microsomes are isolated from ethically sourced, non-diseased human small intestine tissue and enriched for membrane-bound enzymes involved in Phase I metabolism, particularly cytochrome P450 enzymes. These microsomes provide a reliable in vitro model for evaluating intestinal first-pass metabolism, CYP enzyme activity, and drug-drug interactions relevant to orally administered compounds.
Prepared under optimized conditions to preserve enzymatic function, our intestinal microsomes are especially suited for studying major intestinal enzymes such as CYP3A4, CYP2C9, and CYP2J2. Microsomes are available with or without PMSF (phenylmethylsulfonyl fluoride). The PMSF-free microsomes, included in our standard stock, are specifically suited for esterase activity studies, where serine protease inhibitors may interfere with enzymatic performance. Both formats are rigorously tested to ensure enzymatic integrity and lot-to-lot consistency.