Our human skin microsomes are isolated from ethically sourced, non-diseased human skin tissue and enriched in enzymes, with a focus on high carboxylesterase activity. These microsomes provide a relevant in vitro model for studying dermal metabolism, especially the hydrolysis of topically applied prodrugs, cosmetics, and environmental chemicals.
Carboxylesterases are the primary metabolic enzymes in skin microsomes and play a crucial role in cutaneous drug activation, detoxification, and local biotransformation. Each batch is carefully processed to maintain enzymatic integrity, ensuring consistent performance for drug development and toxicological screening applications.