Metabolic-derived stellate cells are isolated from livers affected by metabolic disorders, including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), type 2 diabetes (T2D), and various fibrotic liver diseases.
 
These cells play a central role in fibrosis development by responding to metabolic and inflammatory stress with extracellular matrix production and secretion of pro-fibrotic and pro-inflammatory factors. They offer a physiologically relevant model for studying liver fibrosis progression, metabolic inflammation, and the evaluation of anti-fibrotic and metabolic therapies.
 
Customers can customize their order by selecting the disease background (NAFLD, NASH, T2D, or fibrotic liver disease) and the differentiation status—quiescent or activated stellate cells. Additionally, you may request supplementation with isogenic human hepatocytes, liver-specific extracellular matrices (ECMs), or other related primary cell types by simply leaving a comment when placing your order.
 
All cells are supplied with full donor history and quality control documentation, ensuring reliability and reproducibility for your preclinical research and drug development studies.