Primary Cell Technologies
3D cultures for translational research
Why 3D cultures will soon change the drug discovery
Human cells, when non-cultured for long retain the original phenotype of the human tissue, including the disease. Numerous research show that it is possible to use patient-derived 3D cultures for therapeutic activity predictions for specific patient.
Design your clinical study and do it on the well-plate
Assemble the patient cohort, who are willing to donate their residual surgical specimen to a study
Create a model, suitable to represent your target disease
Select an assay, which will show your drug in action
You will get:
Clinical Utility Analysis
Analysis of safety and efficacy
Go/No-Go decision advise
Patient-guided drug optimization
3D modeling of the tissue can resolve a long-standing problem of translatability of the currently used disease models. We produce a variety of models for the multiple uses. We concentrate on human-derived primary models, developing strong clinical network for biospecimen procurement.
Gastrointestinal tumors: with respect
to heterogeneityeriment range as
2D gastrointestinal & metastatic cancer monolayers
3D gastrointestinal tumor spheroids
3D colorectal tumor organoids
Gastrointestinal tumors: with respect to heterogeneity
Glioblastoma growth factors strongly different from those typically used for the other solid tumor growth. Nevertheless, primary cultures hold strong potential to produce new drugsto treat brain tumors.We produce astrocyte-tumor co-cultures for the purposes of GBM drug development.
Right assay for the right cell
Other models available
- Cell viability
- Apoptosis detection
- Reporter-based assays
3D breast cancer spheroids
Human airway cells 2D Lung
3D spheroids are the most robust models, available in cell biology toolbox to model the heterogeneous tissues.
Nevertheless, those models suffer from high variability from well-to-well to donor-to-donor. This motivated us
to develop high-throughput microfluidic technology, which leads to the faithful, thus general tissue modeling.
mixture of cells from homogenized tissue
The system produces over a 10,000 spheroids/hour/chip
Procedure can be staтdardized, and enhance the experiment reproducibility
Procedure can incorporate wide array of cell types
Agnostic of the tissue-specific growth condidition