Custom hECM isolation
Preci has developed propietary flexible technology allowing the generation of human-derived ECM models applicable for the wide range of organ systems. Over the time we have generated the range of the products, including cancer-derived ECM hydrogels, liver-derived ECM hydrogels, etc.
Low ischemia human tissue is carefully collected from the clinical site and preserved for a further use
Cellular contents are meticulously washed out using detergents, DNAase, and saline solutions
Formed decellularized mash is dispersed within the chaotropic solution, containing surfactants in order to generate the dispersion.
The additives are washed out and the basal medium is added in order to generate the most biocompatible product
Controls
DNA content
AFM-based visualisation
Gelation efficiency
Biocompatibility
Lipid content
Protein integrity
Project Execution
5-10 business days for project execution
Experimental support and custom method development
Payment upon delivery
Can be combined with the cellular projects
Custom cell isolation services
Primary cell products are increasingly used in drug discovery due to their ability to more accurately reflect human biological processes compared to immortalized cell lines or animal models. These cells retain the physiological characteristics of their tissue of origin, providing a closer approximation of human responses to drug candidates. This is particularly important in studying disease mechanisms, toxicity, drug metabolism, and efficacy. As a result, primary cell models reduce the translational gap between preclinical studies and clinical outcomes, enhancing the success rate of drug development while reducing costs and time to market.
Tissue procurement for primary cell modeling typically involves a highly controlled process to ensure the quality and viability of the biospecimens.
Tissue digestion optimization is a critical step in isolating viable primary cells from solid tissues, and it involves fine-tuning multiple parameters to balance yield, cell viability, and functionality.
After tissue digestion, primary cells are purified and identified through a series of steps to ensure a high-quality, homogenous population.
Properly validated QC and storage protocols ensure that the cells retain their viability and functionality for reliable, reproducible research.
Project Execution
5-10 business days for project execution for projects without cultivation
Experimental support and custom method development
Payment upon delivery
Can be combined with the cellular projects