Custom cell isolation services
Primary cell products are increasingly used in drug discovery due to their ability to more accurately reflect human biological processes compared to immortalized cell lines or animal models. These cells retain the physiological characteristics of their tissue of origin, providing a closer approximation of human responses to drug candidates. This is particularly important in studying disease mechanisms, toxicity, drug metabolism, and efficacy. As a result, primary cell models reduce the translational gap between preclinical studies and clinical outcomes, enhancing the success rate of drug development while reducing costs and time to market.
Tissue procurement for primary cell modeling typically involves a highly controlled process to ensure the quality and viability of the biospecimens.
Tissue digestion optimization is a critical step in isolating viable primary cells from solid tissues, and it involves fine-tuning multiple parameters to balance yield, cell viability, and functionality.
After tissue digestion, primary cells are purified and identified through a series of steps to ensure a high-quality, homogenous population.
Properly validated QC and storage protocols ensure that the cells retain their viability and functionality for reliable, reproducible research.
Adherence to stringent QC and optimized storage protocols is essential for generating high-quality primary cell models, which are critical for accurate drug discovery. Maintaining cell viability, functionality, and phenotypic stability throughout isolation, purification, and storage ensures that these models reliably mimic in vivo human biology. Each step—whether optimizing tissue digestion, purifying cells with high specificity, or employing advanced QC measures—directly influences the cells’ performance in assays, including their metabolic activity, response to drugs, and genetic integrity. Deviation from these principles can lead to compromised cell quality, resulting in unreliable data or failed experiments.