Human Liver Microsomes Production
Fast track your drug testing
ADME-Tox on scale
Why human liver microsomes are considered essential for hepatic ADME studies?
Human liver microsomes are indispensable in drug discovery programs for evaluating the pharmacokinetics and metabolism of new compounds. They provide a precise representation of phase I human liver enzyme activity, which is crucial for predicting drug interactions and metabolic pathways. Human liver microsomes are fundamental for ADME research, offering reliable and reproducible data essential for high-throughput screening and drug development.
Robustness
Human liver microsomes are a crucial instrument of ADME evaluation:
Drug-drug interaction assays
Toxicology assays
Microsomal clearance assays
CYP inhibition assays
Automatability
Easy to employ in your high-throughput screening
Transporter expression
CYP activity
Drug response
HBV uptake
Tailor your microsome assay kits to perfection
Model-Kit-Validation as a ready-to-use product for your DMPK assays
Pre-validation of CYP content using qPCR microarrays (80 CYPs and 20 oxidases screened)
Ensured CYP diversity and batch-to-batch reproducibility
Pooling with consideration of CYP polymorphisms
Preplated to the 96-well format - one-step protocol
CV < 5%
Standard and consistent well filling
Available for the customization
Secure your long-term supply
No-Stock Production Business Model
Biopredic and Preci produce and stock single-donor batches for 3 years based on your order.
Pooling and shipping on agreed schedule
Batch qualification with <10% enzyme level divergence guaranteed
Microsomes
50 Single-donor batches
200 - 400 vials from a single donor booked for 3 years
Pooled microsomes
Sub-batch size - 1500 vials
Potential volume - 10,000-20,000 vials
Quality standard and assurance
Factors in batch-to-batch variation and their mitigation strategies
Polymorphisms
Individual Donor Variability
mRNA-based profiling
Subcellular Contaminants
TEM-based quality control
Liver Ischemia
Cryopreservation of the tissue 2 hours since donation
Technology instability
No execution time deviation via automation
Highly standardised temperature controls
Colloidal size variation
DLS-monitored production
Quality standard and assurance
Batch acceptance standards for DMPK use:
> Confirmed CYP content and activity
> 20 mg/mL protein content
> HBV, HCV, HIV-free
NUNC vials, suitable
for dispatch automation
Automation for vial
filling with <10% variability
Ethics
Preci LLC is committed to deliver the fully ethically sourced products of human origin. Our donor involvement is compliant with modern EU requirements, Human Tissue Act UK and US regulations.
You can validate the compliance by asking on hi@preci.care or by visiting our Scientist.com account.