Primary human pulmonary fibroblasts are isolated from healthy or diseased lung tissue and play a crucial role in maintaining extracellular matrix homeostasis, tissue repair, and wound healing within the lung microenvironment. These cells are key contributors to fibrotic remodeling and are actively involved in the progression of pulmonary diseases such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and acute respiratory distress syndrome (ARDS).
 
Supplied in a cryopreserved format to ensure high viability and functionality after thawing, pulmonary fibroblasts express typical mesenchymal markers including vimentin and alpha-smooth muscle actin (α-SMA). They are ideal for fibrosis modeling, drug discovery, toxicity screening, and studying cellular responses to pro-fibrotic stimuli such as TGF-β. Donor customization options are available upon request to support specific research applications in respiratory health and disease.