Our human proximal tubular epithelial cells (PTECs) are primary cells isolated from healthy human kidney tissue, offering a physiologically relevant in vitro model for studying renal drug transport, metabolism, and toxicity. These cells retain characteristic morphology and functional expression of key transporters such as OAT1, OAT3, OCT2, and megalin, essential for modeling renal drug handling and clearance.
PTECs play a central role in drug absorption, secretion, and metabolism, making them ideally suited for transport assays, renal clearance studies, and drug-drug interaction evaluations. Due to their high sensitivity to nephrotoxic compounds, they are widely used in nephrotoxicity testing and cytotoxicity assays, supporting preclinical safety assessments.