Our human skeletal muscle ECM (hECM) hydrogel, sourced from both healthy donors and individuals with metabolic diseases such as type 2 diabetes, obesity-related metabolic dysfunction, and insulin resistance, provides a physiologically relevant extracellular matrix for in vitro modeling of muscle tissue physiology and metabolic disorders. This hydrogel retains native matrix components, including key structural proteins (collagens, laminins), glycosaminoglycans, and signaling molecules involved in muscle regeneration, metabolism, and inflammation.
 
Ideal for studying muscle insulin sensitivity, lipid accumulation, mitochondrial dysfunction, and chronic low-grade inflammation, the skeletal muscle hECM hydrogel supports advanced applications in metabolic disease research. It is fully compatible with primary human myoblasts, myotubes, and co-cultures with adipocytes and immune cells, enabling the development of complex in vitro models for studying metabolic syndrome, sarcopenic obesity, and therapeutic intervention strategies.
 
Customizable formulations allow for adjustments in matrix stiffness, protein composition, and disease relevance to suit specific research objectives in drug discovery, functional recovery studies, and regenerative medicine.
 
Whether you aim to model healthy liver function or investigate disease progression mechanisms like fibrosis, steatosis, chronic inflammation, and metabolic dysregulation, our hECM hydrogel supports a wide range of applications. It is fully compatible with primary human hepatocytes, hepatic stellate cells, Kupffer cells, and immune cell co-cultures, making it an ideal platform for drug screening, toxicity testing, biomarker discovery, and fibrosis reversal research.
 
Custom formulations are available to tailor ECM composition, stiffness, and disease relevance to meet your specific experimental needs.